Statistical Approaches to Detecting and Analyzing Tandem Repeats in Genomic Sequences
نویسندگان
چکیده
منابع مشابه
Statistical Approaches to Detecting and Analyzing Tandem Repeats in Genomic Sequences
Tandem repeats (TRs) are frequently observed in genomes across all domains of life. Evidence suggests that some TRs are crucial for proteins with fundamental biological functions and can be associated with virulence, resistance, and infectious/neurodegenerative diseases. Genome-scale systematic studies of TRs have the potential to unveil core mechanisms governing TR evolution and TR roles in sh...
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where the pattern composed by the three bases CGG in the left sequence is transformed in five identical and adjacent copies. Additional mutational laws can cause mismatch between the bases of the pattern and the bases of the repeated copies, for this reason sometimes there is no an exact repetition of the pattern but there is an approximate repetition in which every copies of the pattern is qui...
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MOTIVATION AND RESULTS The importance of Tandem Repeats in some genomes is now well established. We have reported elsewhere some interesting new results obtained by means of a preliminary program for finding Tandem Repeats in DNA sequences, together with a brief description of the basic ideas of the algorithm. We describe here a completely new program based only in part on those ideas, we brief...
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A tandem repeat is a sequence of two or more contiguous, approximate copies of a pattern. Tandem repeats occur in the genomes of both eukaryotic and prokaryotic organisms. They are important in numerous fields including disease diagnosis, mapping studies, human identity testing (DNA fingerprinting), sequence homology, and population studies. Although tandem repeats have been used by biologists ...
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A new method for the search of local repeats in long DNA sequences, such as complete genomes, is presented. It detects a large variety of repeats varying in length from one to several hundred bases, which may contain many mutations. By mutations we mean substitutions, insertions or deletions of one or more bases. The method is based on counting occurrences of short words (3-12 bases) in sequenc...
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ژورنال
عنوان ژورنال: Frontiers in Bioengineering and Biotechnology
سال: 2015
ISSN: 2296-4185
DOI: 10.3389/fbioe.2015.00031